She is best remembered for her endearing Southern charm. During her youth she often appeared in religious plays at her church particularly in Christmas pageants. In the 1930s she did stage work and later found herself working in movies.
Her first screen role came in Stage Door (1937) opposite Katharine Hepburn, Ginger Rogers, and Adolphe Menjou.
Her next role came at Warner Brothers Studios playing Spring Byington"s daughter in Jezebel (1938) opposite the likes of George Brent, Bette Davis, and Fay Bainter.
She later became a free lance actress and found herself working in various roles at such studios as Radio-Keith-Orpheum, Warner Brothers, and Metro-Goldwyn-Mayer. Her other screen roles include parts in Judge Hardy and Son (1939), Strike Up The Band (1940), Andy Hardy"s Private Secretary (1941), and Stage Door Canteen (1943).
In 1947 she made her last screen appearance in Cinderella Girl.
She spent the remainder of her days living in Laguna Beach, California being active in the Baptist church and the Republican party. On November 29, 2000, Margaret Early died at her home in Laguna Beach, California, from congestive heart failure at age 80.
She was good friends with Cheryl Walker, Mickey Rooney, Bette Davis, Ginger Rogers, Katharine Hepburn, Laraine Day, Henry Fonda, Cary Grant, Joel McCrea, and Dennis Morgan.