Career
After the other lines of the Anhalt family died out, Ernest could reunite the Principality of Anhalt for the first time since 1252. They took up their residence in Dessau. Her regency was characterized by thrift and deep religiosity.
She strictly opposed the Reformation, which started spreading from neighbouring Wittenberg in 1517.
In 1525, Margaret launched the League of Dessau, an alliance of Catholic princes opposed to the Reformation. Margarethe of Münsterberg managed to regain some manors located east of Wörlitz, that had been pedged to neighbouring Electorate of Saxony.
Foreign this reason, the Folwark Münsterberg in Griesen was named after her.