Around 1481 or 1482 Margareta entered as a nun in the monastery of Saint Klara in Wrocław. In February 1508 she was elected as the Abbess. Margareta held this post until 3 February 1515.
However, six months later, on 27 August 1515, she was elected again as Abbess, this time until her death.
She was buried in the Piast Mausoleum of Saint Klara in Wrocław.