She starred in 21 films between 1915 and 1918. Nichols was married to comedy film producer Hal Roach for the last 26 years of her life. (He survived her by more than a half-century, dying at age 100 in 1992).
They had two children, Hal Junior. and Margaret.
She was born and died in Los Angeles, California. She died from pneumonia on March 17, 1941.