Born in Rome, Maria Rosaria Omaggio debuted in 1973 in the Italian show Canzonissima. In 1976 she made her film debut with two "poliziotteschi" alongside Tomas Milian, Rome Armed to the Teeth and The Cop in Blue Jeans, and later starred in numerous films and television-series. She is also active on stage, and in 2011 celebrated her 25th year in theater with the recital Omaggio a voi.
Her last film is Walesa.
Manitoba of Hope, directed by Andrzej Wajda, where she stars as Oriana Fallaci. She is a goodwill ambassador for United Nations International Children's Emergency Fund.