She died as a result of childbirth. Her maternal grandparents were Archduke Ferdinand of Austria-Este and Maria Beatrice Ricciarda d"Este. Maria Beatrice was the eldest daughter of Ercole III d"Este and Maria Teresa Cybo-Malaspina, Duchess of Massa and Princess of Carrara.
On 10 July 1872 she was declared to be a Servant of God, on 6 May 1937 a Venerable Servant of God, and on 3 May 2013 Pope Francis authorised a decree recognising a miracle due to her intercession, a further stage on her process to beatification.
Her beatification took place on 25 January 2014 at the Basilica of Santa Chiara, where she is buried, making her Blessed Maria Cristina of Savoy. Titles and styles 14 November 1812 – 21 November 1832: Her Royal Highness Princess Maria Cristina of Savoy, Princess of Sardinia 21 November 1832 – 21 January 1836: Her Majesty The Queen of the Two Sicilies Posthumously: 10 July 1872 – 6 May 1937: Servant of God Maria Cristina of Savoy, Queen of the Two Sicilies 6 May 1937 – 25 January 2014: Venerable Servant of God Maria Cristina of Savoy, Queen of the Two Sicilies 25 January 2014 – present: Blessed Maria Cristina of Savoy, Queen of the Two Sicilies.