She was nicknamed the "Beauty of the Screen" (Arabic: حسناء الشاشة). Mariam Fakhr Eddine"s first film appearance was in the 1951 film A Night of Love and she went on to appear in the films The Murderous Suspicion (1953), Devil of the Sahara (1954), The Love Message (1954) and A Window on Paradise (1954). In the late 1950s and early 1960s, she initially found success in larger sentimental roles before transitioning into portraying matriarch late in her career.
In 2007, Mariam Fakhr Eddine was cast as Mistress
Aida in the French-Canadian romantic drama film Whatever Lola Wants. She attended the Alexandria International Festival in 2009.
Until her death in 2014, Fakhr Eddine appeared in more than 200 films. Her younger brother, Youssef Fakhr Eddine, was also a leading actor.
She was born in Faiyum, Middle Egypt to a Circassian father and a Hungarian mother.
Her younger brother is actor Youssef Fakhr Eddine (1935–2002). She was educated at a German high school. She was discovered by director Mahmoud Zulficar whom she married in 1952.
Her first film appearance was in the 1951 film A Night of Love.
The film was entered into the 5th Cannes Festival. She went on to appear in the films The Murderous Suspicion (1953), Devil of the Sahara (1954), The Love Message (1954) and A Window on Paradise (1954).
A few months after brain surgery, Fakhr Eddine died on 3 November 2014, at the Maadi Armed Forces Hospital in Cairo. Following a religious funeral held at the Maadi Military Hospital Mosque, she was buried in 6th of October City, Giza Governorate.