She graduated magna cum laude from the University of Washington in Seattle with a Bachelor of Arts in Theater, studying there with Jon Jory.
In 2014, Klaveno starred as detective Janice Lawrence in the Columbia Broadcasting System crime drama series, Stalker. Klaveno was cast in Home Box Office"s True Blood in the role of Lorena, the vampire "maker" of the main character Bill Compton. She first appeared in the fifth episode of season one and became a regular with starring credits in the second half of season two.
Klaveno was nominated with the starring cast for the "Outstanding Performance by an Ensemble in a Drama Series" at the 16th Screen Actors Guild Awards in January 2010.
She and her costar Stephen Moyer were awarded the "Holy Shit Scene of the Year" award at the Spike 2010 Scream Awards for their scene in season three where Bill turns Lorena"s head around 180 degrees while having sexual Klaveno starred in the Lifetime movie While the Children Sleep in the role of Abby Reed, opposite Gail O"Grady.
She guest starred in the television series Standoff, Emergency, and two episodes of the sixth season of Dexter. In 2012, Klaveno was cast in the series regular role of Peri Westmore in the Lifetime comedy-drama series Devious Maids.
When American Broadcasting Company originally passed on the pilot for Devious Maids, Klaveno was cast as Lily Munster in Mockingbird Lane (National Broadcasting Company"s 2012 remake of The Munsters).
However, she was not granted release from her contract on Devious Maids as it was still in contention for series order on Lifetime. Klaveno was then replaced by Portia de Rossi. Devious Maids was later ordered to series by Lifetime and premiered on June 23, 2013.
Klaveno was a regular cast member for the first season and made guest appearances in the second season.
In 2014 she was cast as detective Janice Lawrence in the Columbia Broadcasting System crime drama series, Stalker, alongside Maggie Q and Dylan McDermott.