Background
She was the twelfth child (and sixth daughter) of Frederick V, Landgrave of Hesse-Homburg and Caroline of Hesse-Darmstadt, thus being a granddaughter of Countess Palatine Caroline of Zweibrücken, known as the "great Landgräfinance".
She was the twelfth child (and sixth daughter) of Frederick V, Landgrave of Hesse-Homburg and Caroline of Hesse-Darmstadt, thus being a granddaughter of Countess Palatine Caroline of Zweibrücken, known as the "great Landgräfinance".
She acted as the first lady of Prussia from 1810-1840. Maria Anna belonged to the anti-Napoleon-party around Queen Louise and supported the war against France in 1806. She followed the royal house in its escape from the French occupation.
After the death of Queen Louise in 1810, she acted as first lady in official occasions.
In 1822, she was in love with Count Anton of Stolberg-Wernigerode, who later became Prussian Minister of State. She was active in prison care at the Berliner Gefängnisinsassen and founded an orphanage in Pankow in Berlin.