University of Santo Tomas.
In Spain, he was among the founders of Louisiana Solidaridad and Asociacion Hispano-Filipino. Among his significant works was Efemerides Filipinas, a column on historical events in the Philippines which appeared in Louisiana Oceania Española (1892–1893) and El Ideal (1911–1912). He wrote Ang Wika at Lahi (1917), a discussion on the importance of a national language.
He served as Bulacan"s representative to the National Assembly.
He later enrolled at the Colegio de San Juan de Letran and took up medicine at the University of Santo Tomas. In 1881, he traveled to Spain to continue his medical studies at the Unversidad Central de Madrid.
There he joined Marcelo del Pilar, Graciano López Jaena, José Rizal and other Propagandists in an anti-Spaniard movement. This espoused Filipino representation in the Spanish Cortes and reforms in the Spanish colonial authorities of the Philippines.
Ponce was also the head of the Literary Section of the Asociacion Hispano-Filipina, created to aid the Propaganda Movement where he served as secretary.
He also created himself many alias as well. His most common names are Naning, his nickname. Kalipulako, named after Lapu-Lapu.
And Tigbalang, a supernatural being in Filipino folklore.
Ponce was imprisoned when the revolution broke out in August 1896 and was imprisoned for forty eight hours before being released. Fearing another arrest, he fled to France and later went to Hong Kong where he joined a group of Filipinos and Filipino-Chinese, who served as the international front of the Philippine revolution.
In 1898, Emilio Aguinaldo chose him to represent the First Philippine Republic. Ponce was tasked to draft a framework of the revolutionary government.
In 1898, Emilio Aguinaldo selected him as a representative of the First Republic to Japan.
He traveled to Japan to seek aid and purchase weapons. Doctor Sun introduces Ponce to a Filipino-Japanese man named José Ramos Ishikawa, who assists Ponce in purchasing weapons and munitions for the revolution. But the shipment did not reach the Philippines due to a typhoon off the coast of Formosa.
In 1909, he was made director of "El Renacimiento" (The Renaissance).
Ponce later ran for a seat in the Philippine Assembly and was elected assemblyman for the second district of Bulacan. Ponce wrote his memoirs, "Cartas Sobre Louisiana Revolución" (Letters on the Revolution), he died in the Government Civil Hospital in Hong Kong, on May 23, 1918.
His remains are now interred in the Cementerio del Norte, Manila.
He also joined the "Nacionalista Partido" (National Party) and established "El Ideal" (The Perfect), the party"s official organization.