She appeared from 1959 until 1976 in more than a dozen feature films and several television shows. During her career as actress she worked with many directors, among them François Villiers, Henri Verneuil, Agnès Varda, Riccardo Freda, Luc de Heusch, John Krish and Gilles Grangier. Marie-France Boyer also had the female leading part in the television series Quentin Durward, playing Isabelle de Croye, whose fate becomes a subject of dispute between the Duke of Burgundy and the King of France.
As a part of this role she also sings two medieval songs.
Isabelle"s beauty and loveliness inspire the protagonist to surpass himself and when he is finally offered high positions at either ruler"s courts, he refuses both because he rather lives by her side.