Her parents were successive rulers of the Latin Empire of Constantinople. In 1217, while attempting to reach Constantinople by land, Peter was taken captive by Theodore Komnenos Doukas, ruler of Epirus. He spent the rest of his life in captivity.
Yolanda reached Constantinople instead and took over the Empire.
Among the alliances negotiated by her was one with Theodore I Lascaris of the Empire of Nicaea. Marie was from 1219 to November, 1221 when Theodore died.
They had no known children. Marie briefly served as a regent of Nicaea in 1222.
In late January, 1228, Robert himself died.
Their younger brother Baldwin II of Courtenay succeeded to the throne. He was only eleven-years-old and thus underage. The barons of Constantinople elected Marie as Regent.
According to Patrick van Kerrebrouck she styled herself Empress.
Her Regency only lasted until her own death eight months later.