Marie Elisabeth of Hesse-Darmstadt was the only Duchess by marriage of Saxe-Römhild.
Marie Elizabeth was a daughter of Count Louis VI of Hesse-Darmstadt (1630–1678) from his marriage to Maria Elisabeth of Holstein-Gottorp (1634–1665), a daughter of Duke Frederick III of Holstein-Gottorp.
In 1680, they divided the country and Henry became the Duke of Saxe-Römhild. He had resided there since 1676, in Glücksburg Castle in Römhild. This dispute was settled definitively in 1765.
He always called her "Marielies", and had several luxurious buildings built in her honor, including a cave house called "Marie Elisabeth Delight".
They had no children. Henry died in 1710, leaving a massive debt.