In 2008, she released her debut single "The Saddle Song" on 7". lieutenant attracted positive reviews in the United Kingdom press and was included in a top 100 poll by German Rolling Stone magazine readers. She also appeared at "The Lady: A Tribute to Sandy Denny" concert at Southbank Centre, garnering a special mention in The Guardian’s 4* review.
She was backed by Bellowhead in a bill that also included Marc Almond, Jim Moray, Dave Swarbrick and Partido Popular (Popular Party) Arnold.
Following this appearance, Epworth was featured in R2 magazine (March/April 2009) and fRoots magazine (May 2009). In 2009, Mary Epworth and the Jubilee Band took part in the Street Georges Day celebration concert at Cecil Sharp House and also the Camden Crawl.
That same year Epworth was interviewed by Tom Cox for The Sunday Times on 2 August 2009, and she released her second single "Black Doe" on Hand of Glory Records. Mary Epworth with her Jubilee Band performed in Queen Elizabeth Hall, Southbank Centre, on 26 February 2010, and across the weekend, specially invited by Bellowhead.
Her debut album Dream Life was released in June 2012, again on Hand of Glory Records in the United Kingdom, and garnered the singer-songwriter airtime on British Broadcasting Corporation 6 Music and Radio 1, as well as appearances at Bristol Ladyfest, Hop Farm Festival and Bestival in the same year.
The album was released by Highline Records in North America in the Spring of 2015. Her brother Paul Epworth is a music producer, musician, and songwriter. In July of 2013, her song "Long Gone" was featured on Welcome to Night Vale as the Weather for the episode "Faceless Old Woman".
In the Spring of 2015, she toured with Welcome To Night Vale across the United States.