In 1982, Meeker joined Merrill Lynch as a stockbroker. After graduate school, she began as an analyst covering the technology sector at Salomon Brothers in 1986. She worked for Cowen during 1990-1991 before moving to Morgan Stanley to specialize in covering the personal computer and consumer software industries.
In the early 1990s Meeker began to appreciate that online connectivity could transform the way people communicate as well as the operation of all industries. She became known as an early Wall Street champion of the Internet.
In December, 2010 Meeker left her position as a managing director at Morgan Stanley and head of the bank's global technology research team to become a partner at the Silicon Valley venture capital firm of Kleiner Perkins Caufield & Byers, where she has participated in over 20 different deals. Meeker serves on the boards of electronic signature provider DocuSign and person-to-person lending company Lending Club.