Career
Early career
Born in Lugo, Romagna, Negrini started his career at Eccellenza Emilia–Romagna club Argentana. In 2003 he was signed by Imolese for 2003-2004 Serie C2, also an Emilia–Romagna team In 2005 he moved back to the Province of Ferrara (where Argentana is located) for SPAL of the provincial capital.
Empoli
In July 2006 Negrini was signed by Serie A club Empoli F.C. Negrini was loaned to Massese, another Tuscan team, for 2006-2007 Serie C1.
On 1 August 2007 Negrini moved to Pro Patria for 2007-2008 Serie C1.
Empoli relegated in 2008, Negrini returned to the club in July but only played 3 times in 2008-2009 Serie B. In January 2010 Negrini transferred to Ternana. He only played 8 times in 2009-2010 Lega Pro Prima Divisione. Alessandria
Negrini was signed by Alessandria in July 2010.