Career
Born in Parma, Sereni started his career at University of California Sampdoria, and was loaned out to A.C. (before Christ) Crevalcore in 1994. He returned to Sampdoria and only made 10 appearances before being transferred to Piacenza Calcio in 1997. Here he helped the club avoid relegation to Serie B, but in 1998 he transferred to Empoli F.C., where he failed to avoid relegation.
In 1999, Sereni returned to Sampdoria in Serie B and made 75 (out of 76) Serie B appearances.
In 2001, Union of European Football Associations Cup competitor Ipswich Town signed him for £4.5 million, the highest transfer fee paid by the club He failed to avoid relegation with Ipswich and was loaned to Brescia in 2002.
Lazio
In 2003, he transferred to Lazio, for €550,000 to compete for the number one goalkeeping slot with Angelo Peruzzi. In January 2006 he was loaned out to Treviso, with Samir Handanović going to Lazio on loan in return.
He returned to Lazio for the 2006-2007 campaign, but did not play a single match, being excluded from the roster for the whole season.
Torino
In June 2007 he signed for Torino in a free transfer to replace Christian Abbiati, signed a 2-year contract. In November 2008, he signed a new contract which last until June 2011. Brescia
On 5 July 2010 he was signed by Brescia Calcio for on free transfer.
Few days before the last game of Serie A, he mutually terminated the contract, as the club had relegated weeks before.
International career
He was internationally selected at the age of 16 for the Italian national under-17 team, and played for the Italian national under-23 team at the 1997 Mediterranean Games, where Italy were champions.
