Fitzgerald graduated from Springside School in Philadelphia, Pennsylvania, and earned a Bachelor of Arts in Drama and Literature from the University of Pennsylvania.
She played Carol Fitzpatrick, assistant to C. J. Cregg, on. In 1990, Melissa met actor Noah Emmerich, who acted in such movies as, Beautiful Girls, and Miracle. Melissa herself appears an extra in and can be seen in the dance scene, where she is one of the other people dancing.
They are now divorced.
Melissa"s resumé states that she is a ranked tennis player and skilled in badminton, hiking, horseback riding, whitewater rafting, fencing.