Mesrop was born in the Ottoman Empire but eventually lived in Isfahan, Persia, where he contributed in the making of manuscripts for bibles and gospels for four decades. Mesrop of Khizan was born to Armenian parents in circa 1560 and is believed to be from the region of Khizan (now known as Hizan) near Lake Van located in the Ottoman Empire.
He was also a scribe, clerk, teacher, doctor of theology, restorer and binder. His manuscripts have been displayed in museums throughout the world and are found in many prestigious libraries. The Armenians of Khizan were noted for illuminated manuscript making and would later be regarded as the Khizan School of art
After Abbas I of Persia defeated the Ottoman Empire around Lake Van, he forcibly relocated many Armenians of the region to his new capital of Isfahan in 1604.
Mesrop of Khizan"s career spans four decades, with his last known artwork dated in 1651.
