In 1868 Malke joined the Saffron Monastery where he studied Syriac, Arabic and Turkish beside theology.
He became the Syrian Catholic eparch of Gazarta (modern Cizre). On 8 August 2015, Pope Francis approved his beatification after he determined that Malke was killed in hatred of the faith. He was beatified on 29 August 2015, the centenary of his martyrdom.
He belonged to a Syriac Orthodox family which hails from Kharput.
He was consecrated a deacon in 1878 and a secretary of the library and a teacher in the monastery"s school. He was ordained a priest in Aleppo on 13 May 1883 and was assigned to various villages in Tur Abdin.
The following years he served as a visiting priest in several sacked villages in Tur Abdin where he helped with the rebuilding efforts. In 19 Januari 1913 he was consecrated a bishop together with the future patriarch Gabriel Tappuni in Beirut.
He was arrested by Ottoman authorities on 28 August 1915, alongside the Chaldean bishop of the city, Philippe-Jacques Abraham.
In 2010 the Syriac Catholic Patriarch launched a request for the beatification of Michael Malke. He was declared Servant of God by the Holy See, which is the first step towards sainthood. On Sunday, 30 September 2012, a report was submitted to Rome by the Syriac Catholic Patriarch for March Michael Malke"s beatification.
On 8 August 2015 his beatification was approved after Pope Francis determined that Melki was killed in hatred of his faith.
Cardinal Angelo Amato - on behalf of the pope - presided over the beatification in Lebanon on 29 August 2015.
His church and house were sacked and burned during the massacres of 1895 which also led to the murder of many members of his parish including his mother.