Student, Oberlin College, 1961. Doctor of Medicine (Life Insurance Medical Research Fund fellow), University Chicago, 1966. Doctor of Philosophy, University Chicago, 1967.
Intern in pathology Albert Einstein College Medicine, New York City, 1967-1968, fellow in neuropathology, 1968-1970, assistant professor pathology, 1969-1974. Staff scientist National Institutes of Health, Bethesda, Maryland, 1971-1973. Visiting scientist Institute Pasteur, Paris, 1973-1974.
Associate professor neuropathology Harvard University, Cambridge, Massachusetts, 1974-1978. Senior research associate, assistant neuropathologist Children's Hospital Medical Center, Boston, 1974-1978. Professor, chairman department pharmacology New York University Medical Center, New York City, 1978-1986.
Delafield Professor, chairman department pathology College Physicians and Surgeons, Columbia University, since 1987. Director pathology services Presbyterian Hospital, since 1987. Co-director Taub Institute for Research on Alzheimer's Disease and the Aging Brain, since 1998.
Member Neurology A study section National Institutes of Health, 1974-1978. Pharmacological Sciences study section, 1986-1990. Member science and medical advisory board Alzheimer's Disease and Related Disorders Association, 1985-1992, secretary, 1987-1992, member Zenith award panel, 1993-1995.
Chairman overhead powerline advisory panel State of New York, 1981-1987. Director Alzheimer's disease research center Columbia University, since 1989. Member American Cancer Society IRG Panel, 1989-1993, science advisory board Dystonia Association, Amyotrophic Lateral Sclerosis Assn.
Elected member, Institute of Medicine, 1999.
Served as senior assistant surgeon United States Public Health Service, 1971-1973. Member American Society Cell Biology, Institute Medicine National Academy of Sciences, American Association Neuropathologists, Association Medical College Pharmacologists, American Society Neurochemistry, American Association Physicians.
Married Vivien Brodkin, June 9, 1963. Children: Howard, Samuel, Noah.