Career
He used material from his heroin addiction, which began at age 15, and his recovery in brutally honest, profanity-laced routines. He was also a drug counselor to others His first gig was in Florida, and that convinced him there was something to live for, and that he had options outside of taking his own life.
His second gig was at a Narcotics Anonymous convention in Atlanta, Georgia, where he stepped before the microphone after a rained-out pool party and started ranting about drugs.
A regular at clubs in New York and around the country, DeStefano gained popularity after appearing on television on Comedy Central’s Live at Gotham. He also appeared on Late Night with Conan O"Brien, Showtime"s Whiteboyz in the Hood and other radio and television shows, and at popular comedy festivals, most notably United States Comedy Arts Festival and Montreal"s Just for Laughs festival.
In 2010, he competed in the seventh season of National Broadcasting Company"s Last Comic Standing and finished in fourth place. On October 9, 2010 DeStefano appeared with Jim Norton, Rich Vos and Robert Kelly in the Comedy Central stand-up special "Comics Anonymous".
All four comedians appearing in the special were former addicts who had been clean and sober for 10 years or more.
On March 6, 2011, Mike DeStefano died as a result of a heart attack. His death came hours after filming a video for funnyordie.com. DeStefano"s funeral was held three days later on March 9 as well as March 10 at the Schuyler Hill Funeral Home in New New York
Unfinished projects
DeStefano"s death came just days before he was scheduled to perform his one-man show, A Cherry Tree in the Bronx, in New New York