Khoso attended the Sindh University in 1950 and graduated with Bachelor degree in 1954 and after two years, Khoso secured a bachelor"s degree in law from Karachi University.
A jurist, Khoso is a retired Judge who previously served as the Chief Justice of the Federal Shariat Court and served as the interim Prime Minister ahead of the general elections scheduled in May 2013. During his youth, Khoso took active participation in Pakistan Movement and noted Jinnah as his inspiration. Khoso, who is known for his simplicity, began his professional career in 1957 as a lawyer of then West Pakistan Karachi Bench and then became a Supreme Court lawyer in 1980.
He was chosen to become a judge at Balochistan High Court in 1977 and served that position for next two years.
He was reappointed as an additional judge in March 1985 and he was confirmed as a permanent judge of the provincial high court in 1987. He was elevated as the chief justice of Balochistan High Court in 1989.
He was appointed as Governor of Balochistan twice but for brief periods. Firstly he governed the province from 25 June until 12 July in 1990 and from 13 March 1991 until 13 July in 1991.
After reaching superannuation and thus retirement from the judicial services Khoso was appointed as a judge of the Federal Shariat Court that rules according to Islamic injunction.
After assuming his new responsibilities in 1991 the next year he was promoted as the chief justice of the Shariat Court and continued to be so until 1994. Because of his integrity and clean reputation, Khoso currently serves as the Balochistan Chairman of the Zakat Council, a position that demands both uprightness and responsibility. Since long, Khoso has steered clear from politics, focusing mainly to his Zakat Council job.
The Election Commission of Pakistan (ECP) appointed Khoso as the caretaker on 24 March 2013, out of four nominees coming from both the opposition and the dissolved government.
He took oath on 25 March 2013. Federal Cabinet
On 2 April 2013, fourteen-member caretaker federal cabinet, nominated by interim Khoso, took oath at the Presidency.
President of Pakistan, Asif Ali Zardari, administerated the oath to the cabinet. Among the ministers sworn in included Arif Nizami, Sohail Wajahat H Siddique, Shahzada Ahsan Ashraf Sheikh, Malik Habib, Ahmer Bilal Soofi, Doctor Musaddiq Malik, Maqbool HH Rahmatoola, Abdul Malik Kasi, Asadullah Mandokhel, Mir Hassan Domki, Doctor Sania Nishtar, Feroze Jamal Shah Kakakhel, Doctor Younis Soomro and Shahzada Jamal.
The interim cabinet includes seven members from the Punjab, three each from Sindh and Balochistan, and two from Khyber Pakhtunkhwa.