Career
He played club football for Highlanders Football Club and represented the Zimbabwe national football team Born in Gwanda, Masuku began playing football with the youth sides of Gwanda and Amazulu Football Club (Bulawayo). Masuku was capped by Zimbabwe at youth and senior levels while with AmaZulu.
After he retired from playing, Masuku became a football coach.
He has managed Bulawayo side Highlanders. In September Mohammed Fathi resigned and Highlanders assistant coach Mkhuphali Masuku was elevated to caretaker coach and managed to guide the Bulawayo outfit to a respectable third position after winning 10 and drawing two matches.
After winning the 2011 Independence Trophy with Highlanders, he was appointed manager of CAPS United in 2012.