He was one of the authors of the Law of Ukraine about national-individual autonomy (1918) which later was canceled by the Communist regime. On July 27, 1917 he became a Jewish representative at the General Secretariat of Ukraine (regional government of the Russian Republic). After the independence of Ukraine, Zylberfarb became a Minister of Jewish Affairs in Ukraine.
During 1918 to 1920 he was a rector at the Jewish National University and the Society in support of development of Jewish Culture (Culture League) in Kiev.
In 1921 Zylberfarb moved to Warsaw where he headed Organization for Rehabilitation through Training. He died in Otwock in 1934, and was buried in Warsaw.
From the very beginning he was a member of the Central Council of Ukraine (March 1917) as member of the United Jewish Socialist Workers Party. Zylberfarb was a member of Little Council. During the October Revolution Zylberfarb became a member of the Regional Committee in Protection of Revolution in Ukraine.