On 1 June 1949, emir Idris declared the "independence" of Cyrenaica. Although this independence could be considered nominal because of the high British influence, forming a new government was necessary. After a short-lived government under Omar Pasha El Kikhia, Muhammad Sakizli formed a new cabinet in March 1950.
After King Idris I of Libya declared its independence 24 December 1951, Sakizli"s title changed to be "Governor" of Cyrenaica and remained in that post until May 1952.
In May 1952, Sakizli was appointed minister of education in the Libyan federal government. Then, In September 1953, he was appointed the chief of the royal bureau.
In February 1954, Sakizli was assigned to form a government., but his cabinet didn"t persist for lougitude On 5 April 1954, The Libyan supreme court issued the decision that the royal order, issued on 19 January 1954, ordering the legislative council of Tripolitania to be dissolved, is cancelled.
Consequently, protests erupted in Tripoli, organized by Tripolitania’s governor As-Siddig al-Mutassir, against the court’s decision which cancelled the King Idris’s order.
On 7 April, the cabinet was summoned, while the Tripoli protests was going on, and governor al-Mutassir is continuing to run the legislative elections, which means actually the defying of the court’s decision. Consequently, Sakizli telephoned King Idris to order governor al-Mutassir to stop the elections, which, apparently, the King doesn’t agree with. The next day, a royal message was delivered to Sakizli demanding his resignation.
Sakizli became the governor of Cyernaica again from 26 December 1962, to 26 April 1963, when the federal system in Libya was cancelled.
Died in 1976.