He wrote and acted in Ee Adutha Kaalathu and Left Right Left, which are considered path breakers in their respective genres. Murali Gopy made his debut as an actor and screen writer in the Lal Jose movie Rasikan (2004). He also sung the song Chaanju nikkana in this movie.
His second movie was Blessy"s Bhramaram in which he played the role of Alex Varghese, a self-centred doctor.
As an actor, Murali has been praised for his attention to minute details and realistic acting style. Ee Adutha Kaalathu, scripted by Murali,is considered a pathbreaker in Malayalam cinema, for its innovative method of weaving story threads together.
Ee Adutha Kaalathu was opined to be the cinema of 21st century by stalwart writer North. South. Madhavan. His next screenplay was for Left Right Left, also directed by Arun Kumar Aravind.
The basic essence of the movie is that a man is part deoxyribonucleic acid, part unknown and part what he sees and goes through as a child.
lieutenant is a social thriller set in three periods – the 60s/70s, the 80s/90s and the present. Murali is also a short story writer He published his first short story "Ayur Rekha" in Kalakaumudi in 1991 at the age of 19.
His stories have been compiled together in his book Murali Gopiyude Kadhakal, published by Mathrubhumi Books.
He has also drawn illustrations for The Hindu, Kalakaumudi and District of Columbia Books. As a journalist, he has worked as sub-editor and reporter for The Indian Express, sub-editor and features editor for The Hindu, chief sub-editor with Arab-Allied Media, Dubai, for the sports magazines Cleanbowled and Sports Today and as chief editor of Master of Science in Nursing India Entertainment (India Syndicate).