Nawin Chandra Mishra

Background

Mishra, Nawin Chandra was born on February 2, 1935 in Bhagalpur, Bihar, India. Came to the United States, 1967, naturalized, 1979. Son of Trilochan and Jiweshwari (Choudhary) Mishra.

Education

Bachelor of Science (Honors) 1956, Master of Science.1958.,both from Patna University ( nicknamed as Oxford of the East at that time ). ( Supported by Patna University Merit Scholarship)

Doctor of Philosophy, McMaster University, 1967. ( Supported by Govt. Of Ontario Fellowship)

Postdoctoral training with the Nobel Laureate Professor E.L. Tatum at the Rockefeller University as a Fellow in Medicine supported by Jane Coffin Child fund for Medical research of the Yale University 1967-1969.

Career

Dr. Mishra was Jane Coffin Child Memorial Fund for medical research fellow at the Rockefeller University, New York City, 1967-1969. Research associate with the late Nobel Laureate Professor E.L.Tatum, Rockefeller University, New York City, 1969—1973. DR. Mishra joined the University of South Carolina as an Asssociate University South Carolina, Columbia in 1973 and then became Professor, and Distinguished Professor.

DR.Mishra also served as the Ad Hoc founding Chairman of the Microbiology Dept. at the USC Medical School .

Since 2006 Dr. Mishra is an Emeritus Distinguished Professor of Genetics and Genomics at the University of South Caolina'

DR. Mishra was a visiting Professor at The Max Planck Institute for Molecular Biology in Heidelberg , Germany in 1980 and and at the Genetic Institute in Greenwood , USA in 2004

Fellow Max Planck Institute, Heidelberg, Germany, 1980. Consultant to United Nations, 1990-1993, Novo Nordisk, Denmark, 1993. Member review panel human genome project United States Department Energy, since 1988. and Member of the NIH site visit Panel at the University of Rochester , NY. He was invited to present his research work in Beijing ,China in May 1980 supported by the Rockefeller Foundation when China first opened to the West. He has audience with Chairman Deng in Great Hall in Beijing during his visit to China along with a number of US scientists including 6 Nobelists : However much later Dr. Mishra did not participate in the International Genetics Congress in Beijing in protest to Tinnamen Massacre.

Earlier in 1966 Dr. Mishra has an opportunity to meet Sri Lal Bahadul Shashtri , the Honorable Prime Minister Of India and discussed the virtue of India developing as a compassionate Democracy and the impracticality of total disarmament policy.

Dr. Mishra was also invited to 300th Anniversary of Martin Luther Uninversity in Halle Wittenberg, Germany as a commencement speaker in 1994. Dr. Mishra was also Invited to deliver Commencement speech at NDRI, India in 1988 when consulting for the United Nations / FAO.

Dr. Misra was invited to participate in the energy conference organized by the US Dept. of Energy in Hilton Head , SC in the mid 1980s.

DR. Mishra has been invited to present his work in India ,EU countries , Russia Japan , Thailand , UAE and Australia ; he has been keynote speaker in American Microbiology Society 1992, American Chemical Society Chicago 1997 , International conference in Atlanta 2020 and i Dudai UAE in 2004; Also invited participant in the Prestigious Gordon Conference in CA 1999.. He has trained a large number of Ph.D And Post Postdoctoral students from different parts of world of different genders and nationality. . He has represented American Association For the Advancement of Science in Indian Science Congress in 1980..

Dr. Mishra Had organized two International congresses at the University of South Carolina . He was also instrumental in inviting several Nobel Laureates , National Academy members and other Distinguished Scientists to present their works at the University of South Carolina . Dr. Mishra also persuaded the Board of Trustees of the University of South Carolina to award Honorary Doctor of Philosophy to recognize The Nobelist Karry Mullis , a Native Of Columbia , SC : Dr Mullis, a friend of D. Mishra invented the Polymerase Chain Reaction (PCR) for which he was awarded Nobel Prize.

Achievements

• Nawin Chandra Mishra has been listed as a noteworthy Genetics educator by Marquis Who's Who. He is a Member of Sigma Xi since 1970, and Educator of America Award in 1975; Fellow of the American Association for the advancement of Science since 1988.
  
  He received Rattan Hind Award/ Jewels of India Award in 2014.
  
  
  
  Major Contributions in Science:
  
  Initiated work in Proteomics by examining gene-enzyme relationship ; Established first Gene transfer in Eukaryotes by using temperature sensitive mutants: Creation & characterzation of mutants defective in DNA polymerase and in Exonucrase : First discovery of Beta DNA polymerase in lower Eukaryotes ; Sequencing of good part of Neurospora mDNA and first report of recombination in mDNA by DNA sequencing.
  
  Publications ( Partial list)
  
  Books
  
  · Introduction to Proteomics: Principles and Applications (Methods of Biochemical Analysis Book 146) 2010. John Wiley & Sons, New York- ISBN 978-0471754022 · Nucleases: Molecular Biology and Applications. 1995 Cell Press, Boca Raton, Fl. – ISBN 978-0471394617
  
  · Nucleases 2002 John Wiley and Sons, New York. - ISBN 0-471- 39461-0
  
  · Sciences of Multiomics 2024 Springer – Nature press
  
  Articles
  
  · Mishra NC 1977. Genetics and Biochemistry of Morphogenesis in Neurospora Advances in Genetics 19: 341-407.
  
  · Mishra NC. 1985. Gene Transfer in Fungi. Advances in Genetics 23: 74-178.
  
  · Mishra NC .1991. Genetics and Molecular Biology of Neurospora crassa. Advances in Genetics .29: 2-62
  
  · Mishra N C .2012 Sciences of Proteomics: Historical Perspectives and Possible Role in Human Health Care. Pharmaceutical Production Technology.10.485- 509
  
  · Mishra N C. 2016.Science of Omics: Historical Perspectives and Role in Human Health Care. Integrative Molecular Medicine. 2017. 3. 1-8
  
  · *Mishra NC and SFH Threlkeld. 1967. Variation in the expression of rg mutants in Neurospora. Genetics 55, 113-121.
  
  · Mishra NC 1971. Heterokaryiosis in Neurospora sitophila. Genetics 67, 55- 59
  
  · Mishra N C and E.L. Tatum. 1970a. Phosphoglucomutase mutants of Neurospora sitophila. Proc. National. Academy of Sciences USA. 60, 638-645
  
  · Mishra N C and E.L. Tatum 1970b. Pleiotropy of gene mutations in Neurospora J. Cell Biology. 470. 141
  
  · Mishra N C and E.L. Tatum 1972. Effect of L-sorbose on the polysaccharide synthetase of Neurosora and its relation to morphology. Proc. National Acad. Sciences USA 60. 638-645
  
  · Mishra NC and E.L. Tatum 1973 Non-Mendelian inheritance of inositol-independence in Neurospora. Proc. National. Academy of Sciences USA70.3875-3879.
  
  · Mishra NC, M. C. Niu, and E.L. Tatum 1975 Induction by RNA of inositol independence in Neurospora. Proc National Academy of Sciences.72. 462-465
  
  · Mishra NC, Szabo G. and E.L. Tatum1973 Nucleic Acid Changes in Neurospora. In the Role of RNA in Reproduction and Development (M.C. Niu and S. Segal) 259-268 North Holland Publisher, Amsterdam
  
  Mishra NC 1976. Episome-like behaviour of donor DNA in transformed strains of Neurospora crassa. Nature. 264: 251-3. PMID 137361
  
  Mishra NC.1979 DNA-mediated genetic changes in Neurospora crassa. Journal of General Microbiology. 113: 255-9. PMID 159941 DOI: 10.1099/00221287-113-2-255
  
  Mishra NC Kathryn Hinnant and Emily Cason 1985 New ara-C resistant mutants of the Chinese hamster ovary cells. Genetical Research. 45: 265-77. PMID 4029614
  
  · Cooley M, Mishra NC. (2000) “Genetic analysis of the in vivo role of DNA polymerases in Saccharomyces cerevisiae Current Genetics.” 38: 256-263
  
  · Fehér Z, Mishra NC. (1995) “An aphidicolin-resistant mutant of Chinese hamster ovary cell with altered DNA polymerase and 3' exonuclease activities.” Biochimica Et Biophysica Acta. 1263: 141-6
  
  · Fehér Z, Mishra NC. (1994) “Aphidicolin-resistant Chinese hamster ovary cells possess altered DNA polymerases of the alpha family.” Biochimica Et Biophysica Acta. 1218: 35-47
  
  · Almasan A, Mishra NC. (1991) “Recombination by sequence repeats with the formation of suppressive or residual mitochondrial DNA in Neurospora.” Proceedings of the National Academy of Sciences of the United States of America. 88: 7684-8
  
  · Almasan A, Mishra NC. (1990) “Characterization of a novel plasmid-like element in Neurospora crassa derived mostly from the mitochondrial DNA.” Nucleic Acids Research. 18: 5871-7
  
  · Mishra NC, Almasan A, Cooley M. (1990) “Characterization of eukaryotic DNA polymerases: aphidicolin resistant mutants of Neurospora with altered DNA polymerase.” Progress in Clinical and Biological Research. 344: 295-31
  
  · Almasan A, Mishra NC. (1988) “Molecular characterization of the mitochondrial DNA of a new stopper mutant ER-3 of Neurospora crassa.” Genetics. 120: 935-45
  
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Works

• DR. Mishra has published several books : One of his book has been by Cell Press and others by John Wiley and Sons : His book entitled Introduction to Proteomics has been endorsed by the Nobel laureate Professor Gunter Blobel.

  • DR. Mishra has published several books : One of his book has been by Cell Press and others by John Wiley and Sons : His book entitled Introduction to Proteomics has been endorsed by the Nobel laureate Professor Gunter Blobel.

Membership

Fellow American Association for the Advancement of Science. Member General Society of America (chair program committee 1977-1979, organization committee 46th annual meeting 1978), American Society Cell Biology (congressional liaison committee since 1993).

Personality

Dr. Mishra help establish a graduate fellowship in Genetics at the University of South Carolina more than 30 years ago to preserve the memory of his first graduate student Kathryn Hinnant , MD who was on the faculty of New York University and worked as Physician at the Bell View Hospital in New York where she was murdered by a lunatic on January 7 , 1989.

Dr. Mishra also raised fund every Christmas for over 35 years to support The Oliver Gospel Mission who provides selter to homeless persons in Columbia SC.

Dr. Mishra has developed a passion to support Danny Thomas Children Hospital in Memphis , TN .

Interests

• Avocations: Sanskrit Scripture and philology.

• Philosophers & Thinkers

  Lord Krishna and his philosophy as depicted in Bhagwad Gita

• Politicians

  Mahatma Gandhi ,Dalai Lama and Robert Oppenheimer

• Writers

  Premchandra

• Artists

  Piccasso and Mithila Paintings

• Music & Bands

  Indian Classical Music and songs of Meera , a 16th centuary poetess

Connections

.

Father:

Trilochan Mishra

Mother:

Jiweshwari (Choudhary) Mishra

Spouse:

Purnima

child:

Prakash Mishra

child:

Rashmi Mishra

child:

Kirin Mishra