She was educated at the Notre Dame Academy, Patna and completed her undergraduate education at Delhi"s Indraprastha College.
She has appeared in several advertisements and videos for firms since her graduation. She holds two Dan black belts in Taekwondo and represented India in the 1997 World Taekwondo Championships in Hong Kong. Neetu Chandra"s brother is Nitin Chandra who also directed the movie Deswa.
She entered Hindi film industry in 2005 with Garam Masala in which she portrayed Sweety, an airhostess.
She also acted in Godavari, a Telugu film, in 2006. In 2007 she appeared in Madhur Bhandarkar"s film, Traffic Signal.
In 2008, she had four releases, being directed by Dibakar Banerjee, Rahul Dholakia, Ashwini Dheer and Vikram. Her Tamil film, Yavarum Nalam with Madhavan, released in 2009, was declared a major hit.
In 2010 she was seen in four Hindi films, Rann, Apartment, chak de india, in which she made a special appearance, Sadiyaan and Jag Mundhra"s Apartment, and one Tamil film, Theeradha Vilaiyattu Pillai.
In 2013, she acted in the Tamil gangster film Ameerin Aadhi Baghavan with Jayam Ravi. She has completed filming for a Greek film Home Sweet Home, in which she plays an Indian girl. She had to learn Greek for the film and also dubbed herself.
She has two Hindi films, Kusar Prasad Ka Bhoot and Shooter, coming up.
In 2008, 7Seas Technologies launched a 3D mobile game, Neetu — The Alien Killer, with Neetu Chandra as the lead character. Neetu was featured on the cover of the January 2009 issue of Indian Maxim.
Neetu began a relationship with actor Randeep Hooda in mid 2010 but the couple parted ways in 2013.
She is a Life Member of International Film And Television Club and International Film And Television Research Centre of Asian Academy of Film & Television.