From 1927 to 1929 he was a student of Kiev Institute of Art, from where he moved to Moscow Institute of Cinematography, from which he graduated in 1932.
The literary debut of Nosov was in 1938. In 1938 Nosov began to publish his stories, including Zatejniki (Russian: Затейники, roughly translates as Jokers). Alive Hat, Cucumbers, Miraculous Trousers, and Dreamers.
These stories were published mainly in the magazine for children Murzilka and many of them make up the foundation of the Nosov's first collection Rat-tat-tat, 1945). Nosov introduced a new hero, naïve and sensible, naughty and curious fidget obsessed by craving for activities and always getting into unusual, often comic situations – into children's literature. The most popular works became his stories for teenagers Merry Family (1949), The Kolya Sinitsyn's Diary (1950), Vitya Maleev at School and at Home (1951).
This last one received State Stalin Prize in 1952. Long-term fame and love of readers were gained by his fairy stories about Dunno (Neznaika). The first of those is the fairy tale Vintik, Shpuntik and vacuum cleaner.
Further the hero appeared in the famous trilogy consisting of fairy tale novels The Adventures of Dunno and His Friends (1953–1954), Dunno in Sun City (1958), and Dunno on the Moon (1964–1965). The writer is also the author of an autobiographical work Story about My Friend Igor (1971–1972) and a memoirs narrative Mystery on a Well Bottom (1977).
USSR Union of Writers.