During high school, he attended the prestigious Saint Ignatius High School. Lowe attended The Catholic University of America, majoring in drama.
He was responsible for the Nextwave title, along with The Eternals by Neil Gaiman. While there he participated in school plays and musicals. Lowe began his comics career as an intern at Marvel Comics during the inception of the Marvel Knights line.
Commenting his fanlike enthusiasm for handling art by notable artists, Lowe recalls, "The best thing was making copies, which sounds insane, I know, but it was photocopying comic art.Come on! John Romita Junior., Frank Quitely, Joe, Carlos Pacheco, Barry Windsor Smith—it was awesome.
I ran errands, filed things, organized comics, et cetera The most unexpected was when Axel Alonso asked me to read the first Incredible Hulk issue of his editorial run and offer feedback and suggestions.
That was a blast. Lowe has edited many books in the Ultimate Marvel line, notably Ultimate Spider-Manitoba, The Ultimates, and Ultimate Iron Manitoba, the book for which he brought noted novelist Orson Scott Card to the Marvel fold.
Lowe also worked on Neil Gaiman"s 1602, The Eternals, Supreme Power, The Punisher: Born and Runaways. He was made the editor on X-Men after Axel Alonso left that position.