At first Nissho was a priest of the Tendai Sect on Mount Hiei. Becoming aware of discrepancies between the original doctrine of the Tendai Sect and the teachings of Jikaku and Chisho, great Tendai Sect priests, and learning that Nichiren's doctrine bridged the discrepancies, he went to Kamakura (1253) and became his disciple. He subsequently stayed in Kamakura and taught other followers of Nichiren. Nissho also founded the Myohoji temple in Echigo Province (Niigata Prefecture) and the Myohokkeji temple in Izu Province (Shizuoka Prefecture).
He was uncle to Nichiro, another disciple of Nichiren.