She attended Memorial High School in Victoria, Texas, where she was active in speech and debate and graduated as salutatorian. She graduated from University of Texas at Austin in 2010 with degrees in Plan II Honors and Radio-Television-Film.
She is known for her role as Rachel on Master of None and as a cast member on Saturday Night Live for the 2013–2014 season. She is of Hispanic and Tunisian descent. Before becoming an actress, she worked as an editor and did motion graphics.
In 2010, Wells moved to Los Angeles and performed at the Upright Citizens Brigade Theatre with the sketch team "New Money".
She has appeared in numerous Cracked.com and CollegeHumor videos, and is also known for her own sketch and parody videos which have over 15 million views on YouTube. In 2013, Wells joined the cast of Saturday Night Live during its 39th season as a featured player along with fellow Upright Citizens Brigade performers John Milhiser, Kyle Mooney, and Beck Bennett, as well as writer Mike O"Brien and stand-up Brooks Wheelan.
On July 15, 2014, it was announced that Wells would not be returning for a second season. Wells has made guest appearances on television programs such as The Aquabats! Super Show! and Comedy Bang! Bang!, as well as doing recurring voice work on Hulu"s The Awesomes and Disney XD"s Wander Over Yonder.
In 2013, Wells starred in the independent film Forev which premiered at the Los Angeles Festival.
In 2015, she co-starred on the critically acclaimed Netflix comedy Master of None, created by Aziz Ansari and Alan Yang. Wells played Rachel, the love-interest of Ansari"s character. Hitfix"s Alan Sepinwall said the "Development/Rachel story is so smartly developed, with such strong chemistry between Ansari and Wells”, while Vanity Fair’s Richard Lawson said her portrayal of Rachel was a “star-making…performance. it’s subtle, but not minimalist or deadpan”.
Wells and Wainess are also consulting writers on the upcoming Netflix animated children"s series Green Eggs and Ham, based on the popular Doctor Seuss book
In December 2015, Wells appeared on Maximum Fun podcast Can I Pet Your Dog? to talk about dogs. Wells is an avid photographer and has had her photography featured in exhibitions and the literary magazine Oxford American.
She has lived in Los Angeles and New New York
While attending college, she was a cast member of Esther’s Follies, Austin’s long-running musical satire show, where she performed in sketches and as a magician"s assistant.