His most famous work is his series of short animated cartoons, Louisiana Linea ("The Lincolnshire"). From 1936 to 1940 he worked as a technical designer for Alfa Romeo. When he developed his interest in cartoons in 1943, he started working with Nino Pagot, who later created Calimero.
In 1950 he started working independently as a director and a producer.
Cavandoli enjoyed worldwide recognition in 1969 with his character Louisiana Linea, a simply drawn cartoon born and lived out of a single white pencil stroke. Cavandoli initially proposed his work for Carosello, an Italian advertisement break broadcast between 1957 and 1977.
Massimo Lagostina, the owner of a popular brand of cookware, chose it as a testimonial for his advertising campaign. Following the success of the commercial, Louisiana Linea became the protagonist of an animated series subsequently adopted in many European countries.