Background
Agutter, Paul Samuel was born on July 14, 1946 in Glossop, Great Britain. Son of Walter and Alice (Currie) Agutter.
(The means by which proteins and RNAs are exchanged betwee...)
The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.
http://www.amazon.com/gp/product/3662225042/?tag=2022091-20
(In the last decade nucleo-cytoplasmic transport has devel...)
In the last decade nucleo-cytoplasmic transport has developed into one of the most active areas of research in cell biology and its significance for cell biology as a whole has been recognised. It has led to elucidation of the mechanisms of major cellular functions such as protein synthesis and cellular differentiation. It is also helping to bring about a synthesis of ultrastructural, biochemical, molecular biological and biophysical approaches to the study of cellular organisaton and function. These theoretical advances have been made possible chiefly by advances in technology - improved methods of gene manipulation and sequencing, of monoclonal antibody production and the use of protein chemistry, of microscopy and of cell manipulation including micro-injection methods. Developments in molecular biology, such as the search for sequence - specific DNA binding proteins and the identification of their binding domains, have also furthered advances in cell biology and these areas have become increasingly integrated with some well-established areas of biochemistry. This book aims to be an introduction, for senior undergraduates and postgraduate biologists, to the field of nucleo-cytoplasmic transport and its relevance to cell biology and seeks to use recent advances in the field to illustrate the process by which modern scientific progress occurs - the importance of developing techniques for formulating problems as well as answering them and the integration of different approaches leading to the evolution of novel concepts. The author assumes a basic general knowledge of molecular and cell biology and of biochemistry, but provides all the necessary background for discussion of recent advances and in the final chapters discusses the actual and potential contributions of the field of nucleo-cytoplasmic transport to cell biology.
http://www.amazon.com/gp/product/0412321904/?tag=2022091-20
Agutter, Paul Samuel was born on July 14, 1946 in Glossop, Great Britain. Son of Walter and Alice (Currie) Agutter.
Bachelor of Science in biochemistry, University Edinburgh, Scotland, 1968; Doctor of Philosophy, University Edinburgh, Scotland, 1971.
Postdoctoral fellow, London University, 1971-1974; postdoctoral fellow, St. Andrews University, Scotland, 1974-1976; lecturer, Napier University, Edinburgh, 1976-1980; senior lecturer, Napier University, 1980-1984; reader, Napier University, 1984-1995; retired, Napier University.
(In the last decade nucleo-cytoplasmic transport has devel...)
(In the last decade nucleo-cytoplasmic transport has devel...)
(The means by which proteins and RNAs are exchanged betwee...)
(London published Biology)
Member Biochemical Society.
Married Alexandra Jean Laird Shorthose, June 2, 1976. 1 child, Beatrice.