She started out in the movie business when she was 20 years old as an assistant to Tómas Gislason. During that time, Gislason was closely connected to Lars von Trier, and she got to listen to Gislason and von Trier"s discussions about movies. In 1993, she went to The European Film College where she met and collaborated with Nanna Arnfred.
Her first feature film, En Soap (English title: A Soap), came out in 2006 and centered on the relationship between a female beauty shop owner and the transsexual living downstairs.
The movie starred Trine Dyrholm as the beauty shop owner and David Dencik as the transsexual Veronica, and was written as a collaboration between Pernille Fischer Christensen and Kim Fupz Aakeson. The movie was also nominated for 15 Robert Awards, including Best Movie and Best Screenplay.
Her next feature film is called Dancers, and the writing has again been a collaboration between Pernille Fischer Christensen and Kim Fupz Aakeson. As was the case in A Soap, the movie starred Trine Dyrholm.
The movie also starred Anders West. Berthelsen and Birthe Neumann.
The Danish newspaper Information has listed Dancers as one of the 10 most expected movies of 2008. Her 2010 film, A Family, was presented at the 60th Berlin International Film Festival.