Background
Born in Schwerin, she was the only daughter of Duke Louis of Mecklenburg-Schwerin, second son of Christian Louis II, Duke of Mecklenburg-Schwerin, and Princess Charlotte Sophie of Saxe-Coburg-Saalfeld. On 21 October 1774 in Copenhagen, she married Hereditary Prince Frederick of Denmark and Norway, the son of King Frederick V of Denmark and his second wife Juliane Marie of Brunswick-Wolfenbüttel, who was the regent in Denmark between 1772 and 1784.