Career
Vicenza
A product of Atalanta"s fruitful youth academy, Simone joined Vicenza from Atalanta in a co-ownership deal in 2003 which became full-ownership one year later. Atalanta
On 4 January 2008, Vicenza signed Zampagna (€19M) and Brivio (€075M) outright. With the remain 50% registration rights of Padoin was sold from Vicenza for €1.55 million.
Padoin added three more years to his contract on 13 May 2009, which took his deal to June 2013.
After the end of the 2009-2010 Serie A season, he was borrowed by Juventus for their United States tour, along with 4 other players. He played a few games for Juventus in their post-season tour and then returned to Atalanta for their own preseason work.
Juventus
On 31 January 2012, he permanently moved to Juventus for a fee of € 5 million in 4½ year contract. On 17 March of the same year, he scored his first goal with Juventus in away match against Fiorentina which ended 5–0, he scored the 5th goal.
On 22 December 2014, in the 2014 Supercoppa Italiana final against Napoli in Doha, Padoin came on as a substitute for Stephan Lichtsteiner after 79 minutes.
In the resulting penalty shootout, which went to sudden death, he had the decisive spot-kick saved by Rafael, handing Napoli the victory. Padoin has been praised by his managers for his work-rate, consistency, tactical intelligence, and versatility, as he is capable of playing in several positions, and adapting himself to different formations. Although he usually plays anywhere in midfield, throughout his career he has also been deployed in defence, as a full-back, as a central defender, and as a wing-back.
He has also functioned as a central midfielder, as a defensive midfielder, as an offensive midfielder, and as a winger.