In 2009 he celebrated his 45th career anniversary. Ramon Ayala started playing the accordion in 1951. He learned to play the drums in 1954.
In 1955, he picked up the bajo sexto after his father Pedro Ayala, El Monarca del Acordeón, showed him his first two chords.
Since 1956, Ramon Ayala has gone on to record for over a dozen studios releasing 88 recordings in album, single, cassette and Civil Defense formats. Ramon Ayala has recorded with Freddy Fender, Paulino Bernal and Esteban Jordan, among others
To date, he has released 105 recordings.