Career
Her only sibling to live past the age of five was Frederick William, Elector of Hesse however. In addition, she had eight half-siblings by her father"s second marriage to Emilie Ortlöpp, Countess of Reichenbach-Lessonitz. Marie Frederica"s paternal grandparents were William I, Elector of Hesse and Wilhelmina Caroline of Denmark and Norway.
Her maternal grandparents were Frederick William II of Prussia and Frederika Louisa of Hesse-Darmstadt.