Career
Little is known about the life of Nicolaus. He is probably the same physician who is mentioned by George Acropolites as being eminent in his profession, but very ignorant of natural philosophy. He was at the court of John III Doukas Vatatzes at Nicaea, when the eclipse of the sun took place October 6 1241, that shortly preceded the death of the empress Irene.
All this agrees very well with the scattered notices of his date and his personal history that we find in his own work.
He mentions Mesue the Younger, who died 1015. "Michael Angelus regalis," who is probably Michael VIII Palaiologos who began to reign 1259.
"Papa Nicolaus," who seems to be Pope Nicholas III, who began to reign 1277. And "Dominus Joannes," and "Magister Johannes," who is probably Joannes Actuarius, who lived in the 13th century.
He mentions his having visited or lived at Nicaea, and also Alexandria, whence he is sometimes called Nicolaus Alexandrinus.