Yácono made his debut for River Plate in a game against Newell"s Old Boys in 1938. He went on to make 393 appearances which puts him in 5th place in the all-time table. After leaving River Plate in 1953 he played for América in Mexico.
He then played for Montréal Alouettes / Concordia in Canada, winning a national title in 1959.
After retiring as a player in the early 1960s Yácono returned to Argentina where he worked as the manager of Sportivo Italiano, Lanús and Godoy Cruz. Later in his career he took up a position of youth team coach for River Plate.
After he immigrated to the United States of America and lived in New Jersey, he was still very active with soccer and became the coach for Iberia Airlines of Spain in the New York Airlines Soccer League, which does not exist any more. That was in the early 70s.
Through the efforts of Norberto Yacono, Iberia Airlines was able to incorporate in the team recently retired players from Argentina, such as Norberto Troilo and Guillermo Heredia.