Background
Brunton was born in Roxburgh in southeastern Scotland, the son of James Brunton (1781-1863) and his second wife Agnes Stenhouse (1807-1848).
Brunton was born in Roxburgh in southeastern Scotland, the son of James Brunton (1781-1863) and his second wife Agnes Stenhouse (1807-1848).
He studied medicine at the University of Edinburgh, beginning research into pharmacology while still a student there, and receiving a gold medal for his 1866 thesis on digitalis.
James"s first wife was Euphemia Lauder (1794-1822), which gives explanation for his middle name, although he was not directly related to the Lauder"s of the Bass. Following additional work in Austria, the Netherlands, and Germany, Brunton returned to University College, London, and while there he was selected for a position at Saint Bartholomew"s Hospital. Brunton"s clinical use of amyl nitrite to treat angina was inspired by earlier work with the same reagent by Arthur Gamgee and Benjamin Ward Richardson.
Brunton reasoned that the pain and discomfort of angina could be reduced by administering amyl nitrite to open the coronary arteries of patients.
In 1874, Brunton was made a Fellow of the Royal Society. He delivered the Goulstonian Lecture in 1877 on "Pharmacology and Therapeutics" and the Croonian Lecture in 1889 on "The Chemical structure of Physiological Action", both to the Royal College of Physicians.
Brunton married Louisa Jane, daughter of the Venerable Edward Adderley Stopford, Archdeacon of Meath, in 1879. She died in 1909. Brunton died in London in September 1916, aged 72, and was buried in Highgate Cemetery.
Some of his papers are held at the National Library of Medicine.
Royal Society.