Career
In her twenties, Talley performed improv comedy in Chicago at the Improv Institute and The Second City. They also appeared together in the May 1996 video for "Tonight, Tonight" by The Smashing Pumpkins as a married couple who take a honeymoon on the moon. Talley"s vocal work includes playing Karen, computer wife of Plankton on SpongeBob SquarePants, as well as Gretchen, the tomboyish alligator Squirrel Scout, the scholarly giraffe named Nina, and the largely angry warthog named Mississippi
Mucus on Camp Lazlo.
She also voices Sarah Dubois on the Adult Swim show The Boondocks. She also voiced Lady Granite in the Plastic Manitoba District of Columbia Nation Shorts. She had voiced Maja the Sky Witch in the Adventure Time episode "Sky Witch.".