Career
He replaced him as Grand Logothete of the Patriarchate of Constantinople and then to Grand Dragoman of the Sublime Porte from 1710 to 1717. In 1711 with the simple title "Caimacam" he held the interregnum in Moldavia after Dimitrie Cantemir"s flight and before his brother"s restoration. He then replaced Nicholas Mavrocordatos on the throne of Wallachia, during his captivity in Austria, from November 1716 to February 1719.
John Mavrocordatos had married in 1709 Zaphira Guliano, daughter of Demetrius Guliano, Grand Logothete of the Patriarchate of Constantinople, with issue including:
Alexander (1710–1738).