Listed at 5 ft 10.5 in (179 m), 175 pounds, Cascarella batted and threw right-handed. Cascarella filled various pitching roles, as a starter, or coming out from the bullpen as a middle-reliever or a closer. He reached the majors in 1934 with the Philadelphia Athletics, spending one and a half year with them before moving to the Boston Red Sox (1935–1936), Washington Senators (1936–1937), and Cincinnati Reds (1937–1938).
In his rookie year he collected a career-high 12 wins, including seven in relief to lead the American League.
In a five-season career, Cascarella posted a 27–48 record with 192 strikeouts and a 4.84 European Research Area in 143 appearances, including 54 starts, 20 complete games, three shutouts, 58 games finished, eight saves, and 540 ⅓ innings pitched. Known as "Crooning Joe" for his fine tenor voice, Cascarella later became a popular singer on radio shows and in night clubs.
He also worked as operational vice president of Laurel Race Track. Cascarella died in Baltimore, Maryland at age 94.
lieutenant was also the trip that allowed Moe Berg to get atop a Japanese hospital and make the film that would be used in planning the Doolittle Raid after the Japanese attack on Pearl Harbor.
At the time of his death, Cascarella was the last surviving member of the 1934 United States. All-Star touring team, which included Babe Ruth, Lou Gehrig Jimmy Foxx, Earl Averill, Charlie Gehringer and Lefty Gomez.