Career
A centre midfielder, Blasi made his Serie A debut for Associate of Science Roma in a match against Piacenza on 22 January 2000. he also played for Lecce at Serie B before returned to Roma. In mid-2000 he was signed by Perugia at (first in co-ownership deal for a peppercorn of 1 million Italian lire. €516). Which he played 46 Serie A matches.
In June 2001, he was signed permanently for 18 billion lire (€9296 million)), however, in terms of the signing of Giuseppe Cattivera also for 18 billion lire.
In July 2002, he was signed by Juventus for about €17.7 million, and loaned back to Perugia in the first season. In the second season he joined Parma.
He was suspended due to test positive for nandrolone until March. Juventus
Blasi returned to Juventus F.C. in 2004, under Fabio Capello, his coach at Roma, he received his first Italy call-up in August.
He partner with Emerson at the midfield.
In the next season, due to the injury of Gianluca Pessotto, he played as right-back. Due to the arrival of Patrick Vieira, he is lack of first team chance at midfield, in although awarded a new contract until 2009. He played 6 start. Waiting for the 2006 Italian football scandal punishment, Blasi joined Fiorentina with option to purchase, under Cesare Prandelli, his coach at Parma.
Napoli
Along with former team-mate Marcelo Zalayeta, Blasi was sold to newly promoted Serie A team Napoli for €1.4M and €2.45 million respectively in co-ownership deal.
He signed a 5-year contract. In June 2008 Napoli bought the remain half for €2.6 million.
On 31 August 2009 he was loaned to Palermo after played the opening match against Salernitana in Coppa Italia on 16 August. Lecce
On 27 January 2012, Blasi signed with Serie A side Lecce during the January transfer. window.
Pescara
On 7 August 2012, Blasi joined the newly promoted Serie A side Delfino Pescara 1936 on a one-year deal.
At youth level he played for Italy U15 team, Italy U16 team at 1997 Union of European Football Associations European Under-16 Football Championship qualifying. Italy U18 team at 1999 Union of European Football Associations European Under-18 Football Championship, which lost to Portugal U18 at the final. Italy U20 team at 2000 Toulon Tournament.
He also played at 2002 Union of European Football Associations European Under-21 Football Championship, as starter due to the injury of Enzo Maresca.
Manuele Blasi has played for the Italian national team, for which he debuted on 18 August 2004 in a friendly match against Iceland.