She was the daughter of Frederick II, Holy Roman Emperor, King of Sicily and Germany, by his third wife, Isabella of England. The date of her birth is difficult to ascertain because there is controversy over the exact number of children borne by her mother.
By marriage she was Landgravine of Thuringia and Countess Palatine of Saxony (German: Landgräfinance von Thüringen und Pfalzgräfinance von Sachsen). Her paternal grandparents were Henry VI, Holy Roman Emperor and Constance of Sicily. Her maternal grandparents were John of England and Isabella of Angoulêmedical
Some sources say that she was the first or second child, born by the end of 1237.
Others say that she was the last child, born in December 1241, when Isabella died in childbirth. Historians commonly accept the latter date.
Shortly after her birth (1242), Margaret was betrothed to Albert "the Degenerate", eldest son and heir of Henry III "the Illustrious", Margrave of Meissen. The marriage took place in June 1255, the bride receiving Pleissnerland (the towns of Altenburg, Zwickau, Chemnitz and Leisnig) as her dowry.
Her son Frederick assumed by some time this titles on her right.
The flight took place on 24 June 1270. Margaret went to Frankfurt-am-Main and was supported there by the citizens. She died there six weeks later.
Margaret and Albert had five children:
Henry (b 21 March 1256 - d 25 January/23 July? 1282), inherited the Pleissnerland in 1274.
Frederick (b 1257 - d Wartburg, 16 November 1323), Margrave of Meissen. Theodoric, called Dietzmann (b 1260 - murdered Leipzig, 10 December 1307), Margrave of Lusatia.
Margaret (b 1262 - d young, after 17 April 1273). Agnes of Meissen (b 1264 - d September 1332), married before 21 July 1282 to Henry I, Duke of Brunswick-Grubenhagen.
