Still a teenager, he joined the laboratory for young actors of the production company Vides by Franco Cristaldi and studied acting under the direction of Alessandro Fersen.
He has appeared in more than 70 films since 1961. He made his stage debut in the theater in 1960 in L"arialda directed by Luchino Visconti and his film debut in the 1961 adventure film Romulus and the Sabines by Richard Pottier. He had some leading roles in the first half of the 1960s, including Marco Bellocchio"s Fists in the Pocket and Jean-Luc Godard"s Les Carabiniers, then he was mainly cast in supporting roles.
Masè is also active in the adaptation of the dialogues for dubbing.