Career
She was the first of Sigismondo Pandolfo Malatesta's three wives. Her mother was accused of infidelity with Ugo d'Este, Ginevra's step-brother and he and Parisina were condemned to death by Niccolò when Ginevra was aged six. Five years later Niccolò remarried to Ricciarda di Saluzzo, giving Ginevra two other step-brothers (Ercole and Sigismondo), in addition to her father's other illegitimate children.
On her death in 1440 she was buried in the Tempio Malatestiano. In 1461 pope Pius II accused Pandolfo of several crimes, including killing Ginevra, and excommunicated him.